Aging Frailty
4 clinical trials enrolling >100 patients indicate that MSCs have a positive impact on biological processes connected to aging and demonstrate their safety
Key Insights
Improved physical performance: physical performance improved after allogeneic MSC infusions, measured for instance by the 6-minute walk test. Female sexual quality is also reported to be improved by MSC infusions.
Improved inflammatory bio-markers: the inflammatory levels in the body decreased after allogenic MSC infusions, for instance the serum TNF-α levels decreased. Early and late activated T-cells were also reduced by MSC therapy.
Excellent Safety Profile: Of >100 patients treated no treatment associated adverse event is reported, the worst side-effect being temporary irritation at the injection site