Crohn's Disease

Clinical research is investigating the potential of mesenchymal stem cells (MSCs) in Crohn’s disease. Studies focus on safety, feasibility, and possible immunomodulatory properties, contributing to the evolving evidence base in Inflammatory Bowel Disease (IBD). 

Crohn’s disease is a chronic form of IBD that causes ongoing inflammation of the digestive tract, most often in the small intestine and colon. Common symptoms include abdominal pain, diarrhea, and weight loss. Conventional therapies may reduce inflammation but do not provide a cure, and many patients continue to experience relapses. 

Ongoing MSC clinical trials aim to assess whether their immune-regulating and tissue-repairing properties could support disease management. While research remains at an exploratory stage, these studies are expanding scientific understanding of how cell-based approaches might contribute to future IBD treatment strategies. 

Clinical Trials

Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease: A Randomized Controlled Clinical Trial — Jian Zhang, et al.


 

Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial — Julián Panés, et al.


 

Follow-up Study to Evaluate the Long-term Safety and Efficacy of Darvadstrocel (Mesenchymal Stem Cell Treatment) in Patients With Perianal Fistulizing Crohn's Disease: ADMIRE-CD Phase 3 Randomized Controlled Trial — Damián Garcia-Olmo, et al.




The safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn's disease - a phase 1 trial with three doses — T Dhere, et al.



 

A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn's disease refractory to biologic therapy — Geoffrey M Forbes, et al.




Mesenchymal Stem Cell Injection in Crohn's Disease Strictures: A Phase I-II Clinical Study — Sophie Vieujean, et al.


 

A Phase IB/IIA Study of Allogeneic, Bone Marrow-derived, Mesenchymal Stem Cells for the Treatment of Refractory Ileal-anal Anastomosis and Peripouch Fistulas in the Setting of Crohn's Disease of the Pouch — Amy L Lightner, et al.



 

Long-term Evaluation of Allogeneic Bone Marrow-derived Mesenchymal Stromal Cell Therapy for Crohn's Disease Perianal Fistulas — Marieke C Barnhoorn, et al.