Alzheimer's Disease

2 clinical trials enrolling >40 patients indicate that MSC treatment might have a positive impact on biomarkers with both studies also meeting their primary safety endpoints

Key Insights

Effect on biomarkers: Fluid-based and imaging biomarkers indicated significant improvement in the MSC arms versus placebo.

Clinical Potential: Larger studies are required and are on their way to investigate the efficacy of treatment.

Safety: The safety endpoints in the two studies were met.

Clinical trials

Kim, H.J. et al. (2021) ‘Intracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with alzheimer’s disease dementia: A phase I clinical trial’, Alzheimer’s Research & Therapy, 13(1). doi:10.1186/s13195-021-00897-2.

Brody, M. et al. (2022) ‘Results and insights from a phase I clinical trial of lomecel‐b for alzheimer’s disease’, Alzheimer’s & Dementia, 19(1), pp. 261–273. doi:10.1002/alz.12651.