Chronic Low Back Pain

Clinical studies are exploring Mesenchymal Stem Cells (MSCs) in chronic low back pain (CLBP) to investigate possible regenerative and immune-related effects in spinal health. 

Chronic low back pain is one of the most widespread health issues globally, often linked to degenerative disc disease or other spinal changes. It can significantly reduce quality of life, and current treatments primarily target symptoms. 

MSC research in CLBP aims to understand whether their biological properties may contribute to disc repair or pain modulation. While results are preliminary, ongoing clinical research is expanding insights into regenerative strategies for spinal disorders. 

Clinical Trials

 

Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study — Hermant Kumar, et al. ▾

 

Allogenic bone marrow-derived mesenchymal stromal cell-based therapy for patients with chronic low back pain: a prospective, multicentre, randomised placebo controlled trial — Yves-Marie Pers, et al. ▾

 

Allogeneic mesenchymal precursor cells treatment for chronic low back pain associated with degenerative disc disease: a prospective randomized, placebo-controlled 36-month study of safety and efficacy — Kasra Amirdelfan, et al. ▾