Osteoarthritis

Clinical studies are increasingly exploring the use of Mesenchymal Stem Cells (MSCs) in osteoarthritis. Research focuses on outcomes such as pain relief, improved joint function, and cartilage preservation, gradually contributing to a growing body of knowledge in this field. 

Osteoarthritis is a degenerative joint disease and one of the leading causes of disability worldwide. It develops through progressive cartilage breakdown, often resulting in chronic pain and reduced mobility. While current treatments may alleviate symptoms, they cannot halt or reverse disease progression. 

Ongoing MSC research aims to evaluate safety, feasibility, and potential biological effects such as immunomodulation and cartilage protection. Although findings remain preliminary, the expanding evidence base is shaping our understanding of possible future therapeutic strategies for osteoarthritis. 

Clinical Trials

Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success. — Griffin Copp, et al.



Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study — Lluis Orozco, et al.



Treatment of Knee Osteoarthritis With Allogeneic Bone Marrow Mesenchymal Stem Cells: A Randomized Controlled Trial — Aurelio Vega, et al.



Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial — Jose Matas, et al.



Intra-Articular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo-Controlled Clinical Trial — Woo-Suk Lee, et al.



Long-term efficacy of autologous bone marrow mesenchymal stromal cells for treatment of knee osteoarthritis — José María Lamo-Espinosa, et al.



Human adipose-derived mesenchymal stem cells for osteoarthritis: a pilot study with long-term follow-up and repeated injections — Yang Song, et al.



Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation — Jaskarndip Chahal, et al.



Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial — Yves-Marie Pers, et al.



Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial — Chris Hyunchul Jo, et al.